Services

Our objective is to achieve the best possible outcome for patients and our clients. We deliver more than the sum of our technical skills; our aim is to provide a true partnership. We advise, critique, and challenge; we provide dedication and flexibility.

Health Economics

 

Our health economists deliver comprehensive health economic modelling and evidence generation support, including:

 

  • Model conceptualisation and design
  • Early and global cost-effectiveness modelling
  • Budget impact model development
  • Model validation and verification
  • Payer communication tools
  • Structured expert elicitation to inform model inputs
  • HTA submission development and write-up

 

Our work is supported by advanced technical expertise in Excel-based modelling (including the use of Excel Labs) and R.

 

Literature Reviews

Our systematic review team produce high quality, user-friendly deliverables conducted to international best practice guidelines with search strings independently validated by SCHARR.

 

  • Systematic literature reviews
  • Rapid reviews
  • Targeted literature reviews

Statistics

 

Our statisticians apply advanced statistical methods to generate robust evidence from clinical trial and observational data including:

  • Evidence synthesis
    • Network meta-analyses, including time-varying indirect treatment comparisons (e.g., fractional polynomials, M-splines, piecewise exponential, restricted mean survival time)
    • Population-adjusted indirect treatment comparisons (e.g., MAIC, STC, ML-NMR)
    • Direct meta-analyses
  • Patient-level data analyses
    • Extrapolation of time-to-event outcomes (e.g., parametric survival models, splines, mixture cure models)
    • Utility analyses
    • Post-hoc analysis of clinical trial data (e.g., subgroup analysis, regression modelling, survival analysis)
  • Real-world evidence
    • Study design and execution of real-world evidence research (e.g., comparative effectiveness, healthcare resource use, treatment patterns)
    • Statistical analysis of observational data, including adjustment techniques such as propensity-score matching

 

Value Communication

Our medical writers develop clear and concise written materials, which effectively communicate an evidence-based value proposition.

 

  • Global reimbursement dossiers
  • Global/core value dossiers
  • Value messages & value story slide decks
  • Objection handlers
  • Evidence summaries
  • Publications (abstracts, posters, and manuscripts)

Health Technology Assessment

We support HTA submission development to UK and international agencies, with strategic advice throughout the process.

 

  • Literature reviews
  • Economic modelling
  • Statistical analyses
  • Medical writing
  • Advisory boards
  • Submission preparation
  • Mock appraisals
  • Post-submission support

Commercialisation and Pricing Strategy

Source supports companies with the development and implementation of commercialisation strategies to optimise value for our clients from Phase 1 to  reimbursement success. 

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  • Early launch planning from Phase 1, alignment of regulatory and access considerations
  • Support for innovation pathways to accelerate time to patient access
  • Market sequencing, international reference pricing analysis
  • Commercialisation and pricing strategy formulation
  • Payer, market, and competitive landscape analysis
  • Payer research to understand key value drivers, barriers to reimbursement, willingness-to-pay, payer expectations
  • Payer insights and system preparedness to support uptake post reimbursement
  • Business development market opportunity assessments
  • Access policy and market dynamics
  • System stakeholder engagement

Training

We provide training courses and/or training resources in health economics, economic modelling, systematic literature review, and meta-analysis, which we tailor to our clients’ needs and audience.