Written by Harry Atkins, Assistant Project Manager Today is Rare Disease Day, a day to raise awareness for people across the world living with a rare disease, their families, and those who care for them. Around 300 million people worldwide have been diagnosed...
Written by Amy Crompton, Systematic Review Analyst Previously, we discussed the use of real-world evidence (RWE) in the reimbursement assessment of medical devices. In this latest blog, we present an overview of the RWE framework created by the National Institute for...
Written by Emma Lones, Medical Writer What are rare diseases? In the European Union, a rare disease is defined as a disorder affecting ≤5 in 10,000 persons (1). Using this definition, the global population prevalence of rare diseases is estimated to be between...
Amy Crompton (Systematic Review Analyst) and Tom Macmillan (Consultant – Systematic Review) Hierarchy of evidence Different study designs are often ranked in a hierarchy of evidence based on their validity and robustness. Randomised controlled trials...
Written by Emma Lones, Medical Writer The RNA interference pathway Ribonucleic acid (RNA) is an important macromolecule in cells, involved in turning genetic information encoded by genes (made up of deoxyribonucleic acid [DNA]), into proteins needed by the...
Amy Cromptom (Systematic Review Analyst) and Tom Macmillan (Consultant – Systematic Review) This blog post follows on from ‘Improving your search strategy: Randomised controlled trial filters’. Electronic database searches can be run on multiple platforms. This...
